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sort: . . . . type: relevance . . . . order: ASC range: . . . . max: 5 . . . . start: 0 . . . . limit: 20 filters: state: normal term: Klaudia Regináčová
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list: . . . . . . . . pmid: 37669480 . . . . . . . . title: Oral Selinexor as Maintenance Therapy After First-Line Chemotherapy for Advanced or Recurrent Endometrial Cancer. . . . . . . . . authors: . . . . . . . . . . . . . . . . firstname: Ignace . . . . . . . . . . . . . . . . lastname: Vergote . . . . . . . . . . . . . . . . initials: I . . . . . . . . . . . . . . . . lookup: Vergote I . . . . . . . . . . . . . . . . firstname: Jose Alejandro . . . . . . . . . . . . . . . . lastname: Pérez-Fidalgo . . . . . . . . . . . . . . . . initials: JA . . . . . . . . . . . . . . . . lookup: Pérez-Fidalgo JA . . . . . . . . . . . . . . . . firstname: Erika Paige . . . . . . . . . . . . . . . . lastname: Hamilton . . . . . . . . . . . . . . . . initials: EP . . . . . . . . . . . . . . . . lookup: Hamilton EP . . . . . . . . . . . . . . . . firstname: Giorgio . . . . . . . . . . . . . . . . lastname: Valabrega . . . . . . . . . . . . . . . . initials: G . . . . . . . . . . . . . . . . lookup: Valabrega G . . . . . . . . . . . . . . . . firstname: Toon . . . . . . . . . . . . . . . . lastname: Van Gorp . . . . . . . . . . . . . . . . initials: T . . . . . . . . . . . . . . . . lookup: Van Gorp T . . . . . . . . . . . . . . . . firstname: Jalid . . . . . . . . . . . . . . . . lastname: Sehouli . . . . . . . . . . . . . . . . initials: J . . . . . . . . . . . . . . . . lookup: Sehouli J . . . . . . . . . . . . . . . . firstname: David . . . . . . . . . . . . . . . . lastname: Cibula . . . . . . . . . . . . . . . . initials: D . . . . . . . . . . . . . . . . lookup: Cibula D . . . . . . . . . . . . . . . . firstname: Tally . . . . . . . . . . . . . . . . lastname: Levy . . . . . . . . . . . . . . . . initials: T . . . . . . . . . . . . . . . . lookup: Levy T . . . . . . . . . . . . . . . . firstname: Stephen . . . . . . . . . . . . . . . . lastname: Welch . . . . . . . . . . . . . . . . initials: S . . . . . . . . . . . . . . . . lookup: Welch S . . . . . . . . . . . . . . . . firstname: Debra L . . . . . . . . . . . . . . . . lastname: Richardson . . . . . . . . . . . . . . . . initials: DL . . . . . . . . . . . . . . . . lookup: Richardson DL . . . . . . . . . . . . . . . . firstname: Eva M . . . . . . . . . . . . . . . . lastname: Guerra . . . . . . . . . . . . . . . . initials: EM . . . . . . . . . . . . . . . . lookup: Guerra EM . . . . . . . . . . . . . . . . firstname: Giovanni . . . . . . . . . . . . . . . . lastname: Scambia . . . . . . . . . . . . . . . . initials: G . . . . . . . . . . . . . . . . lookup: Scambia G . . . . . . . . . . . . . . . . firstname: Stéphanie . . . . . . . . . . . . . . . . lastname: Henry . . . . . . . . . . . . . . . . initials: S . . . . . . . . . . . . . . . . lookup: Henry S . . . . . . . . . . . . . . . . firstname: Pauline . . . . . . . . . . . . . . . . lastname: Wimberger . . . . . . . . . . . . . . . . initials: P . . . . . . . . . . . . . . . . lookup: Wimberger P . . . . . . . . . . . . . . . . firstname: David S . . . . . . . . . . . . . . . . lastname: Miller . . . . . . . . . . . . . . . . initials: DS . . . . . . . . . . . . . . . . lookup: Miller DS . . . . . . . . . . . . . . . . firstname: Jaroslav . . . . . . . . . . . . . . . . lastname: Klat . . . . . . . . . . . . . . . . initials: J . . . . . . . . . . . . . . . . lookup: Klat J . . . . . . . . . . . . . . . . firstname: Jerónimo . . . . . . . . . . . . . . . . lastname: MartÃnez-Garcia . . . . . . . . . . . . . . . . initials: J . . . . . . . . . . . . . . . . lookup: MartÃnez-Garcia J . . . . . . . . . . . . . . . . firstname: Francesco . . . . . . . . . . . . . . . . lastname: Raspagliesi . . . . . . . . . . . . . . . . initials: F . . . . . . . . . . . . . . . . lookup: Raspagliesi F . . . . . . . . . . . . . . . . firstname: Bhavana . . . . . . . . . . . . . . . . lastname: Pothuri . . . . . . . . . . . . . . . . initials: B . . . . . . . . . . . . . . . . lookup: Pothuri B . . . . . . . . . . . . . . . . firstname: Ignacio . . . . . . . . . . . . . . . . lastname: Romero . . . . . . . . . . . . . . . . initials: I . . . . . . . . . . . . . . . . lookup: Romero I . . . . . . . . . . . . . . . . firstname: Alice . . . . . . . . . . . . . . . . lastname: Bergamini . . . . . . . . . . . . . . . . initials: A . . . . . . . . . . . . . . . . lookup: Bergamini A . . . . . . . . . . . . . . . . firstname: Brian . . . . . . . . . . . . . . . . lastname: Slomovitz . . . . . . . . . . . . . . . . initials: B . . . . . . . . . . . . . . . . lookup: Slomovitz B . . . . . . . . . . . . . . . . firstname: Fabienne . . . . . . . . . . . . . . . . lastname: Schochter . . . . . . . . . . . . . . . . initials: F . . . . . . . . . . . . . . . . lookup: Schochter F . . . . . . . . . . . . . . . . firstname: Estrid . . . . . . . . . . . . . . . . lastname: Høgdall . . . . . . . . . . . . . . . . initials: E . . . . . . . . . . . . . . . . lookup: Høgdall E . . . . . . . . . . . . . . . . firstname: Lorena . . . . . . . . . . . . . . . . lastname: Fariñas-Madrid . . . . . . . . . . . . . . . . initials: L . . . . . . . . . . . . . . . . lookup: Fariñas-Madrid L . . . . . . . . . . . . . . . . firstname: Bradley J . . . . . . . . . . . . . . . . lastname: Monk . . . . . . . . . . . . . . . . initials: BJ . . . . . . . . . . . . . . . . lookup: Monk BJ . . . . . . . . . . . . . . . . firstname: Dayana . . . . . . . . . . . . . . . . lastname: Michel . . . . . . . . . . . . . . . . initials: D . . . . . . . . . . . . . . . . lookup: Michel D . . . . . . . . . . . . . . . . firstname: Michael G . . . . . . . . . . . . . . . . lastname: Kauffman . . . . . . . . . . . . . . . . initials: MG . . . . . . . . . . . . . . . . lookup: Kauffman MG . . . . . . . . . . . . . . . . firstname: Sharon . . . . . . . . . . . . . . . . lastname: Shacham . . . . . . . . . . . . . . . . initials: S . . . . . . . . . . . . . . . . lookup: Shacham S . . . . . . . . . . . . . . . . firstname: Mansoor Raza . . . . . . . . . . . . . . . . lastname: Mirza . . . . . . . . . . . . . . . . initials: MR . . . . . . . . . . . . . . . . lookup: Mirza MR . . . . . . . . . . . . . . . . firstname: Vicky . . . . . . . . . . . . . . . . lastname: Makker . . . . . . . . . . . . . . . . initials: V . . . . . . . . . . . . . . . . lookup: Makker V . . . . . . . . . . . . . . . . firstname: . . . . . . . . . . . . . . . . lastname: . . . . . . . . . . . . . . . . initials: . . . . . . . . . . . . . . . . lookup: . . . . . . . . citation: J Clin Oncol 2023 Dec 10;41(35):5400-5410. . . . . . . . . published_date: 2023 Dec 10 . . . . . . . . abstract: Selinexor inhibits exportin-1 (XPO1) resulting in nuclear accumulation of tumor suppressor proteins including p53 and has clinical activity in endometrial cancer (EC). The primary end point was to ass . . . . . . . . full_abstract: Selinexor inhibits exportin-1 (XPO1) resulting in nuclear accumulation of tumor suppressor proteins including p53 and has clinical activity in endometrial cancer (EC). The primary end point was to assess progression-free survival (PFS) with once-weekly oral selinexor in patients with advanced or recurrent EC. . . . . . . . . source: Journal of clinical oncology : official journal of the American Society of Clinical Oncology . . . . . . . . doi: 10.1200/JCO.22.02906 . . . . . . . . publication_type: Randomized Controlled Trial . . . . . . . . language: English . . . . . . . . free_article: false . . . . . . . . full_text_links: . . . . . . . . . . . . . . . . is_free_text: false . . . . . . . . . . . . . . . . provider_name: Atypon . . . . . . . . . . . . . . . . link: https://ascopubs.org/doi/10.1200/JCO.22.02906?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub 0pubmed . . . . . . . . . . . . . . . . is_free_text: false . . . . . . . . . . . . . . . . provider_name: Ovid Technologies, Inc. . . . . . . . . . . . . . . . . link: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=37669480.ui . . . . . . . . pmid: 38834399 . . . . . . . . title: Long-term follow-up of efficacy and safety of selinexor maintenance treatment in patients with TP53wt advanced or recurrent endometrial cancer: A subgroup analysis of the ENGOT-EN5/GOG-3055/SIENDO study. . . . . . . . . authors: . . . . . . . . . . . . . . . . firstname: Vicky . . . . . . . . . . . . . . . . lastname: Makker . . . . . . . . . . . . . . . . initials: V . . . . . . . . . . . . . . . . lookup: Makker V . . . . . . . . . . . . . . . . firstname: Jose Alejandro . . . . . . . . . . . . . . . . lastname: Perez-Fidalgo . . . . . . . . . . . . . . . . initials: JA . . . . . . . . . . . . . . . . lookup: Perez-Fidalgo JA . . . . . . . . . . . . . . . . firstname: Giorgio . . . . . . . . . . . . . . . . lastname: Valabrega . . . . . . . . . . . . . . . . initials: G . . . . . . . . . . . . . . . . lookup: Valabrega G . . . . . . . . . . . . . . . . firstname: Erika . . . . . . . . . . . . . . . . lastname: Hamilton . . . . . . . . . . . . . . . . initials: E . . . . . . . . . . . . . . . . lookup: Hamilton E . . . . . . . . . . . . . . . . firstname: Toon . . . . . . . . . . . . . . . . lastname: Van Gorp . . . . . . . . . . . . . . . . initials: T . . . . . . . . . . . . . . . . lookup: Van Gorp T . . . . . . . . . . . . . . . . firstname: Jalid . . . . . . . . . . . . . . . . lastname: Sehouli . . . . . . . . . . . . . . . . initials: J . . . . . . . . . . . . . . . . lookup: Sehouli J . . . . . . . . . . . . . . . . firstname: Klaudia . . . . . . . . . . . . . . . . lastname: RegináÄová . . . . . . . . . . . . . . . . initials: K . . . . . . . . . . . . . . . . lookup: RegináÄová K . . . . . . . . . . . . . . . . firstname: Debra L . . . . . . . . . . . . . . . . lastname: Richardson . . . . . . . . . . . . . . . . initials: DL . . . . . . . . . . . . . . . . lookup: Richardson DL . . . . . . . . . . . . . . . . firstname: Tamar . . . . . . . . . . . . . . . . lastname: Perri . . . . . . . . . . . . . . . . initials: T . . . . . . . . . . . . . . . . lookup: Perri T . . . . . . . . . . . . . . . . firstname: Amit M . . . . . . . . . . . . . . . . lastname: Oza . . . . . . . . . . . . . . . . initials: AM . . . . . . . . . . . . . . . . lookup: Oza AM . . . . . . . . . . . . . . . . firstname: David S . . . . . . . . . . . . . . . . lastname: Miller . . . . . . . . . . . . . . . . initials: DS . . . . . . . . . . . . . . . . lookup: Miller DS . . . . . . . . . . . . . . . . firstname: Eva Maria Guerra . . . . . . . . . . . . . . . . lastname: AlÃa . . . . . . . . . . . . . . . . initials: EMG . . . . . . . . . . . . . . . . lookup: AlÃa EMG . . . . . . . . . . . . . . . . firstname: Ugo . . . . . . . . . . . . . . . . lastname: De Giorgi . . . . . . . . . . . . . . . . initials: U . . . . . . . . . . . . . . . . lookup: De Giorgi U . . . . . . . . . . . . . . . . firstname: Stephanie . . . . . . . . . . . . . . . . lastname: Henry . . . . . . . . . . . . . . . . initials: S . . . . . . . . . . . . . . . . lookup: Henry S . . . . . . . . . . . . . . . . firstname: Daniel L . . . . . . . . . . . . . . . . lastname: Spitz . . . . . . . . . . . . . . . . initials: DL . . . . . . . . . . . . . . . . lookup: Spitz DL . . . . . . . . . . . . . . . . firstname: Pauline . . . . . . . . . . . . . . . . lastname: Wimberger . . . . . . . . . . . . . . . . initials: P . . . . . . . . . . . . . . . . lookup: Wimberger P . . . . . . . . . . . . . . . . firstname: Markéta . . . . . . . . . . . . . . . . lastname: BednaÅÃková . . . . . . . . . . . . . . . . initials: M . . . . . . . . . . . . . . . . lookup: BednaÅÃková M . . . . . . . . . . . . . . . . firstname: Hye Sook . . . . . . . . . . . . . . . . lastname: Chon . . . . . . . . . . . . . . . . initials: HS . . . . . . . . . . . . . . . . lookup: Chon HS . . . . . . . . . . . . . . . . firstname: Jerónimo . . . . . . . . . . . . . . . . lastname: MartÃnez-Garcia . . . . . . . . . . . . . . . . initials: J . . . . . . . . . . . . . . . . lookup: MartÃnez-Garcia J . . . . . . . . . . . . . . . . firstname: Carmela . . . . . . . . . . . . . . . . lastname: Pisano . . . . . . . . . . . . . . . . initials: C . . . . . . . . . . . . . . . . lookup: Pisano C . . . . . . . . . . . . . . . . firstname: Jonathan S . . . . . . . . . . . . . . . . lastname: Berek . . . . . . . . . . . . . . . . initials: JS . . . . . . . . . . . . . . . . lookup: Berek JS . . . . . . . . . . . . . . . . firstname: Ignacio . . . . . . . . . . . . . . . . lastname: Romero . . . . . . . . . . . . . . . . initials: I . . . . . . . . . . . . . . . . lookup: Romero I . . . . . . . . . . . . . . . . firstname: Giovanni . . . . . . . . . . . . . . . . lastname: Scambia . . . . . . . . . . . . . . . . initials: G . . . . . . . . . . . . . . . . lookup: Scambia G . . . . . . . . . . . . . . . . firstname: Lorena . . . . . . . . . . . . . . . . lastname: Fariñas-Madrid . . . . . . . . . . . . . . . . initials: L . . . . . . . . . . . . . . . . lookup: Fariñas-Madrid L . . . . . . . . . . . . . . . . firstname: Joseph . . . . . . . . . . . . . . . . lastname: Buscema . . . . . . . . . . . . . . . . initials: J . . . . . . . . . . . . . . . . lookup: Buscema J . . . . . . . . . . . . . . . . firstname: Fabienne . . . . . . . . . . . . . . . . lastname: Schochter . . . . . . . . . . . . . . . . initials: F . . . . . . . . . . . . . . . . lookup: Schochter F . . . . . . . . . . . . . . . . firstname: Kai . . . . . . . . . . . . . . . . lastname: Li . . . . . . . . . . . . . . . . initials: K . . . . . . . . . . . . . . . . lookup: Li K . . . . . . . . . . . . . . . . firstname: Pratheek . . . . . . . . . . . . . . . . lastname: Kalyanapu . . . . . . . . . . . . . . . . initials: P . . . . . . . . . . . . . . . . lookup: Kalyanapu P . . . . . . . . . . . . . . . . firstname: Christopher J . . . . . . . . . . . . . . . . lastname: Walker . . . . . . . . . . . . . . . . initials: CJ . . . . . . . . . . . . . . . . lookup: Walker CJ . . . . . . . . . . . . . . . . firstname: Ignace . . . . . . . . . . . . . . . . lastname: Vergote . . . . . . . . . . . . . . . . initials: I . . . . . . . . . . . . . . . . lookup: Vergote I . . . . . . . . citation: Gynecol Oncol 2024 Jun ;185():202-211. . . . . . . . . published_date: 2024 Jun . . . . . . . . abstract: To report long-term efficacy and safety of selinexor maintenance therapy in adults with TP53 wild-type (TP53wt) stage IV or recurrent endometrial cancer (EC) who achieved partial remission (PR) or com . . . . . . . . full_abstract: To report long-term efficacy and safety of selinexor maintenance therapy in adults with TP53 wild-type (TP53wt) stage IV or recurrent endometrial cancer (EC) who achieved partial remission (PR) or complete remission (CR) following chemotherapy. . . . . . . . . source: Gynecologic oncology . . . . . . . . doi: 10.1016/j.ygyno.2024.05.016 . . . . . . . . publication_type: Journal Article . . . . . . . . language: English . . . . . . . . free_article: true . . . . . . . . full_text_links: . . . . . . . . . . . . . . . . is_free_text: true . . . . . . . . . . . . . . . . provider_name: Elsevier Science . . . . . . . . . . . . . . . . link: https://linkinghub.elsevier.com/retrieve/pii/S0090-8258(24)00234-8 . . . . . . . . . . . . . . . . is_free_text: true . . . . . . . . . . . . . . . . provider_name: ClinicalKey . . . . . . . . . . . . . . . . link: https://www.clinicalkey.com/content/playBy/pii?v=S0090-8258(24)00234-8 . . . . . . . . pmid: 38667456 . . . . . . . . title: Radiation-Related Fractures after Radical Radiotherapy for Cervical and Endometrial Cancers: Are There Any Differences? . . . . . . . . authors: . . . . . . . . . . . . . . . . firstname: Hana . . . . . . . . . . . . . . . . lastname: Malikova . . . . . . . . . . . . . . . . initials: H . . . . . . . . . . . . . . . . lookup: Malikova H . . . . . . . . . . . . . . . . firstname: Katarina . . . . . . . . . . . . . . . . lastname: Nadova . . . . . . . . . . . . . . . . initials: K . . . . . . . . . . . . . . . . lookup: Nadova K . . . . . . . . . . . . . . . . firstname: Klaudia . . . . . . . . . . . . . . . . lastname: Reginacova . . . . . . . . . . . . . . . . initials: K . . . . . . . . . . . . . . . . lookup: Reginacova K . . . . . . . . . . . . . . . . firstname: Karin . . . . . . . . . . . . . . . . lastname: Kremenova . . . . . . . . . . . . . . . . initials: K . . . . . . . . . . . . . . . . lookup: Kremenova K . . . . . . . . . . . . . . . . firstname: Lukas . . . . . . . . . . . . . . . . lastname: Rob . . . . . . . . . . . . . . . . initials: L . . . . . . . . . . . . . . . . lookup: Rob L . . . . . . . . citation: Diagnostics (Basel) 2024 Apr 12;14(8):. . . . . . . . . published_date: 2024 Apr 12 . . . . . . . . abstract: In this study, we reviewed CT/MRI scans and studied the rates of radiation-related fractures in subjects treated for cervical cancer (CC, 63 subjects) by radical radiotherapy (RT) and in subjects trea . . . . . . . . full_abstract: In this study, we reviewed CT/MRI scans and studied the rates of radiation-related fractures in subjects treated for cervical cancer (CC, 63 subjects) by radical radiotherapy (RT) and in subjects treated for endometrial cancer (EC, 64 subjects) by radical surgery and RT. The differences between bone density measured in L1 on pretreatment CT, age and body mass index (BMI) were evaluated. Despite significant differences in RT total dose, age, BMI, etc., between both groups, the rate of radiation-related fractures was similar: 28.6% of CC versus 26.6% of EC subjects. CC subjects with fractures were significantly older (62.4 ± 10.1 vs. 49.0 ± 12.4 years; < 0.001), and their bone densities were significantly lower (106.3 ± 40.0 vs. 168.2 ± 49.5 HU; < 0.001); no difference in BMI was found. EC subjects with fractures were without significant difference in age but had significantly lower bone densities (103.8 ± 29.0 vs. 133.8 ± 42.3 HU; = 0.009) and BMIs (26.1 ± 4.9 vs. 31.8 ± 6.9 kg/m; = 0.003). Bone density strongly correlated with age (r = -0.755) only in CC subjects. Subjects with fractures from both groups had similarly low bone densities (106.3 ± 40.0 vs. 103.8 ± 29.0 HU; = 0.829); however, no correlation between bone density and BMI was found. The rate of radiation-related fractures in both groups was clearly associated only with low pretreatment bone density, reflecting osteoporosis. . . . . . . . . source: Diagnostics (Basel, Switzerland) . . . . . . . . doi: . . . . . . . . publication_type: Journal Article . . . . . . . . language: English . . . . . . . . free_article: true . . . . . . . . full_text_links: . . . . . . . . . . . . . . . . is_free_text: true . . . . . . . . . . . . . . . . provider_name: MDPI . . . . . . . . . . . . . . . . link: https://www.mdpi.com/resolver?pii=diagnostics14080810 . . . . . . . . . . . . . . . . is_free_text: true . . . . . . . . . . . . . . . . provider_name: PubMed Central . . . . . . . . . . . . . . . . link: https://pmc.ncbi.nlm.nih.gov/articles/pmid/38667456/ . . . . . . . . . . . . . . . . is_free_text: true . . . . . . . . . . . . . . . . provider_name: Europe PubMed Central . . . . . . . . . . . . . . . . link: https://europepmc.org/abstract/MED/38667456 . . . . . . . . pmid: 39113856 . . . . . . . . title: Circulating tumor cells in patients with cervical cancer undergoing chemoradiotherapy combined with brachytherapy. . . . . . . . . authors: . . . . . . . . . . . . . . . . firstname: Klaudia . . . . . . . . . . . . . . . . lastname: Reginacova . . . . . . . . . . . . . . . . initials: K . . . . . . . . . . . . . . . . lookup: Reginacova K . . . . . . . . . . . . . . . . firstname: Eliska . . . . . . . . . . . . . . . . lastname: Pospisilova . . . . . . . . . . . . . . . . initials: E . . . . . . . . . . . . . . . . lookup: Pospisilova E . . . . . . . . . . . . . . . . firstname: Martina . . . . . . . . . . . . . . . . lastname: Kubecova . . . . . . . . . . . . . . . . initials: M . . . . . . . . . . . . . . . . lookup: Kubecova M . . . . . . . . . . . . . . . . firstname: Pavla . . . . . . . . . . . . . . . . lastname: Svobodova . . . . . . . . . . . . . . . . initials: P . . . . . . . . . . . . . . . . lookup: Svobodova P . . . . . . . . . . . . . . . . firstname: Vladimir . . . . . . . . . . . . . . . . lastname: Bobek . . . . . . . . . . . . . . . . initials: V . . . . . . . . . . . . . . . . lookup: Bobek V . . . . . . . . . . . . . . . . firstname: Katarina . . . . . . . . . . . . . . . . lastname: Kolostova . . . . . . . . . . . . . . . . initials: K . . . . . . . . . . . . . . . . lookup: Kolostova K . . . . . . . . citation: Am J Cancer Res 2024 ;14(7):3614-3625. . . . . . . . . published_date: 2024 . . . . . . . . abstract: Circulating tumor cells (CTCs) have significant potential to become an important tool for monitoring the effects of treatment in solid tumors. The present study reports the occurance of CTCs in cervic . . . . . . . . full_abstract: Circulating tumor cells (CTCs) have significant potential to become an important tool for monitoring the effects of treatment in solid tumors. The present study reports the occurance of CTCs in cervical cancer (CC) patients during radical chemoradiotherapy (CRT), including brachytherapy (BRT), and during the follow-up period. Patients diagnosed with CC treated with radical CRT were included in the study (n=30). A total of 167 CTC-tests (MetaCell) were provided at predefined testing time points during the study follow-up (e.g., before CRT, after CRT, every three months of follow-up). In parallel with CTC-testing, SCC-Ag were measured to compare their predictive values during treatment. CTCs were present in 96% (25/26) of patients at the time of diagnosis and in 61% (14/23) after treatment. Patients who relapsed during the 36-month follow-up (n=10) showed an elevation in pre-treatment CTC- numbers, similarly there was a significant increase in pre-treatment SCC-Ag. As next, an increased number of CTCs was observed approximately 12 weeks before relapse was diagnosed by standard imaging modalities (MRI, US, PET-CT) in 3 of 4 patients. In addition to standardized vital cytomorphology of enriched CTCs, quantitative PCR (qPCR) was used to inform the nature of CTCs before treatment. Analysis revealed increased SOX2 and POUSF expression in CTCs in the group of patients with recurrence (P < 0.02). Disease aggressiveness may be related to increased expression of stem cell markers, as found in samples from relapsed patients. CTCs may be an aid to assess tumor burden and disease aggressiveness. An increase in CTCs precedes an increase in SCC-Ag and confirmation of relapse by imaging, as shown in our study. . . . . . . . . source: American journal of cancer research . . . . . . . . doi: 10.62347/QIXJ7103 . . . . . . . . publication_type: Journal Article . . . . . . . . language: English . . . . . . . . free_article: true . . . . . . . . full_text_links: . . . . . . . . . . . . . . . . is_free_text: true . . . . . . . . . . . . . . . . provider_name: PubMed Central . . . . . . . . . . . . . . . . link: https://pmc.ncbi.nlm.nih.gov/articles/pmid/39113856/ . . . . . . . . pmid: 34650341 . . . . . . . . title: Late Radiation-Related Toxicities in Patients Treated for Early-Stage Cervical Carcinoma by Surgery and Adjuvant Radiotherapy: A Retrospective Imaging Study. . . . . . . . . authors: . . . . . . . . . . . . . . . . firstname: Katarina . . . . . . . . . . . . . . . . lastname: Nadova . . . . . . . . . . . . . . . . initials: K . . . . . . . . . . . . . . . . lookup: Nadova K . . . . . . . . . . . . . . . . firstname: Miroslava . . . . . . . . . . . . . . . . lastname: Burghardtova . . . . . . . . . . . . . . . . initials: M . . . . . . . . . . . . . . . . lookup: Burghardtova M . . . . . . . . . . . . . . . . firstname: Klara . . . . . . . . . . . . . . . . lastname: Fejfarova . . . . . . . . . . . . . . . . initials: K . . . . . . . . . . . . . . . . lookup: Fejfarova K . . . . . . . . . . . . . . . . firstname: Klaudia . . . . . . . . . . . . . . . . lastname: Reginacova . . . . . . . . . . . . . . . . initials: K . . . . . . . . . . . . . . . . lookup: Reginacova K . . . . . . . . . . . . . . . . firstname: Hana . . . . . . . . . . . . . . . . lastname: Malikova . . . . . . . . . . . . . . . . initials: H . . . . . . . . . . . . . . . . lookup: Malikova H . . . . . . . . citation: Pathol Oncol Res 2021 ;27():1609915. . . . . . . . . published_date: 2021 . . . . . . . . abstract: Surgical treatment is preferred therapy of early-stage cervical carcinoma. In the risk of cancer recurrence surgery is often followed by adjuvant radiotherapy. In our retrospective study we aimed at i . . . . . . . . full_abstract: Surgical treatment is preferred therapy of early-stage cervical carcinoma. In the risk of cancer recurrence surgery is often followed by adjuvant radiotherapy. In our retrospective study we aimed at identifying late (â¥6 months) and very late (â¥5 years) radiation adverse effects on imaging scans as CT, PET/CT and MRI in patients who underwent successful treatment for cervical carcinoma by radical surgery combined with radiotherapy ± chemotherapy. We correlated imaging results with clinical manifestations. We selected young and middle-aged patients with long life expectancy, as late radiation-related toxicities may significantly affect their quality of life. Patients were selected from those who were primary diagnosed and treated between the years 1987-2011 and regularly visited our Oncology department in years 2011-2012. Following inclusion criteria were applied: age â¤55 years at diagnosis, clinical follow-up â¥5 years and at least one tomography scan â¥3 years after finished treatment. One hundred and three subjects were reviewed: 73 patients met all inclusion criteria, while 30 patients fulfilled the inclusion criteria except for available tomography scan â¥3 years after therapy. The mean imaging follow-up was 11.2 ± 7.6 years and the mean clinical follow-up was 15.0 ± 6.9 years. In 20 (27%) subjects 27 cases grade I radiation-related toxicities were found; 9 (33%) of those 27 cases were clinically silent. In 14 (19%) females only grade I toxicities were observed. Grade III-IV toxicities were found in 5 (6.8%) subjects. No grade V toxicities were observed. We concluded that severe late side effects caused by radiotherapy were exceedingly rare in females successfully treated for early-stage cervical carcinoma, only 1 bilateral osteonecrosis, 2 cases of ileus, and 2 potentially radiation-induced tumors were found. The majority of radiation-related comorbidities found on imaging scans were clinically silent. . . . . . . . . source: Pathology oncology research : POR . . . . . . . . doi: . . . . . . . . publication_type: Journal Article . . . . . . . . language: English . . . . . . . . free_article: true . . . . . . . . full_text_links: . . . . . . . . . . . . . . . . is_free_text: true . . . . . . . . . . . . . . . . provider_name: PubMed Central . . . . . . . . . . . . . . . . link: https://pmc.ncbi.nlm.nih.gov/articles/pmid/34650341/ . . . . . . . . . . . . . . . . is_free_text: true . . . . . . . . . . . . . . . . provider_name: Europe PubMed Central . . . . . . . . . . . . . . . . link: https://europepmc.org/abstract/MED/34650341 . . . . . . . . . . . . . . . . is_free_text: true . . . . . . . . . . . . . . . . provider_name: Frontiers Media SA . . . . . . . . . . . . . . . . link: https://por-journal.com/articles/10.3389/pore.2021.1609915 total_results: 5 total_pages: 1 total_returned: 5
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